I've been using Chrome for around a year now as my primary browser. I like the dev tools that come with it right out of the box, and it's fast enough for my needs. I end up doing web development in some form at home, school, and work, so having the same familiar environment in all of those places is useful.
Since I do web development, I can't just abandon all other browsers unfortunately. I've got IE7/8/9, Firefox, Chrome, and Safari, too. None of them are really that bad, except IE7/8. Those two have been the bane of my existence for a while now. It would be nice if I could just pick my favorite browser and develop using all the newest HTML5 features and all that fun stuff, but typically it goes the other way around: finding the ----tiest browser with significant market share and making something that works on it (which is usually IE7).